LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems?
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چکیده
منابع مشابه
Cellular metabolic response to DNA damage
DNA damage elicits a cellular signaling response that initiates cell cycle arrest and DNA repair. The metabolic response to DNA damage is largely unknown. Here we report a novel metabolic response to genotoxic stress. DNA damage triggers a critical block in the uptake of glutamine, a mitochondrial substrate essential for cellular proliferation. Sirtuins regulate both cellular metabolism and str...
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Altered expression of NEAT1, the architectural long non-coding RNA (lncRNA) of nuclear paraspeckles, has been reported during tumorigenesis, as well as under various cellular stress conditions. Here we report that the depletion of NEAT1 lncRNA alleviates nucleolar stress during RNAP I inhibition through releasing sequestered P54nrb and PSF to facilitate the IRES-dependent translation of c-Myc. ...
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ژورنال
عنوان ژورنال: Non-Coding RNA
سال: 2020
ISSN: 2311-553X
DOI: 10.3390/ncrna6030026